Proceeds raised from the event will be going to chosen charity for the year, the Joe Glover Trust, which works closely with children suffering from cancer.
The line up for the concert includes: Shane Richie & The Prelude, Love Soul Choir, Dude Crew and stars from the West End cast of Les Miserables. The event will also feature rare video and picture archives of the Port of Southampton over the last 175 years.
Doug Morrison, Port of Southampton, Director, said:
"The port is at the heart of the city and the people of Southampton have always been the secret to our success. So, when it came to celebrating our 175th anniversary, we were determined to invite local people into the port to celebrate with us."
"We have assembled a spectacular night of entertainment that will be not only a chance to have fun together but to celebrate the unique relationship between port and city."